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In the radiological examination of the spine one frequently sees in association with kyphoses very varied contours of the upper and lower vertebral margins. Mechanical Compression and Nucleus Pulposus Application on Dorsal Root the disc core is presumed to contribute to intervertebral disc hernia-related pain. This report examines 18 surgically proven L3/4 herniated nucleus pulposus ( HNP), all having myelogram, CT and adequate neurological evaluation. It will focus.

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Effects of nucleus pulposus on nerve root neural activity, mechanosensitivity, axonal morphology, and sodium channel expression. Since a light mechanical compression may reduce transmission in nociceptive pathways, it is possible that the presence or absence of NP is crucial for pain development in the acute phase of disc herniation.

Cervical disc herniations occur in the neck, most often between the fifth and sixth C5—6 and the sixth and seventh C6—7 cervical vertebral bodies. It is located within the annulus fibrosus and between the vertebral body endplates. The combination of mechanical compression and NP might therefore result in further increases in central neuronal activity.

Essential clinical anatomy 3rd ed. uplposus

This method of surgical removal is not possible with normal, pklposus material, which is encountered when healthy interverterbral disks are excised anteriorly in patients having surgery because of deformity or trauma. TNF-alpha enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury.


P values less than 0. After positioning the recording electrode in the contralateral VPL nucleus a series of baseline records were obtained while stimulating the ipsilateral sciatic nerve. Illustration depicting herniated disc and spinal nerve compression.


Nuclear material is normally contained within the annulus, but it may cause bulging of the annulus or hernia nukleus pulposus herniate nulleus the annulus into the spinal canal.

Application of nucleus pulposus to L5 dorsal root ganglion in rats enhances nociceptive dorsal horn neuronal windup. If the fissures reach the periphery of the anulusthe nuclear material can pass through as a disc herniation.

The boxes in the left panel indicate the intervention performed on day 1 for each group of animals.

Lateral L3/4 herniated nucleus pulposus: clinical and imaging considerations.

Epidural corticosteroid injections provide a slight and questionable short-term improvement for those with sciatica, but are of no long-term benefit. Experimental set-up with stimulation and recording sites.

Example of a herniated disc at L5—S1 in the lumbar spine. Following a midline incision, the left facet joint between the fourth and fifth lumbar vertebrae L4—L5 was removed to expose the L4 DRG.

A recent study reported that NP applied to a DRG results in increased neuronal activity in the thalamus. D ICD – Find articles by Helena Brisby. In other projects Wikimedia Commons. The investigator performing the test was blinded with regard to the surgical intervention. Please review our privacy policy. The contribution of ischaemia and deformation to the conduction block generated by compression of the cat sciatic nerve. It is composed of a thin lattice of collagen fibres type II which traverse though hydrophilic glycosaminoglycans.


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Spinal disc herniation

The electrode track and recording site corresponding to d in the schematic drawing in A is indicated by a dotted vertical line and a filled circle. You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. The thalamus is the major brain relay nucleus for sensory information, including transmission in nociceptive pathways from the spinal cord en route to cortical regions where the information is processed further.

The hydraulic effect hernia nukleus pulposus the contained, hydrated nucleus within the annulus acts as a shock absorber to cushion the spinal column from forces that are applied to the musculoskeletal system. Herniations usually occur postero-laterally, at the points where the anulus fibrosus is relatively thin and is not reinforced by the posterior or anterior longitudinal ligament.

A preliminary case control study of Indian population.

There are a number of non-surgical methods used in attempts to relieve the condition. Read it at Google Books – Find it at Amazon. J Bone Joint Surg Am. Am J Phys Med Rehabil. Analysis Original data records from the electrophysiological experiments were stored online using a software system designed by E.

Protection from disc herniation is best provided by core strength and an awareness of body mechanics including posture.