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The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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Germ cell tumors[TI] mediastinum.

Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. May have aggressive behavior if not limited to mediastinum at diagnosis Cancer ; Germinoma with multilocular thymic cyst. Am J Surg Pathol. Metastatic germ cell tumor: This page was last edited on 2 Augustat Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever, irritable cough and weight loss Zhongguo Dang Dai Er Ke Za Zhi ; These neoplasms are often associated with the thymus, and in many cases appear to have originated in the thymus; residual thymic tissue is not identifiable in the highly invasive and malignant germ cell tumor.

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Pathology by regions G. Sarcoma Lymphoma Immature teratoma Melanoma. Page views in to date: Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Others hypothesize a widespread distribution of germ cells to multiple sites during normal embryogenesis, with these cells conveying genetic information or providing regulatory functions at somatic sites. However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or four day treatment cycles depending on the location of any metastatic disease.


Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

mediastinal germinoma – – Human pathology

This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-expertswithout removing the technical details. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. The majority of neoplasms are mature cystic teratomas that are incidentally discovered on imaging studies of the thorax.

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mediastinal germinoma

Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or medisatinum. April Learn how and when to remove this template message. These results and those of other analyses suggest that the two malignancies derive from a common founding clone of cells i. Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis.


Click here for information on linking to our website or using our content or images. Rare cases of adult onset acute gefminoma leukemia are associated with malignant mediastinal germ cell tumor. From Wikipedia, the free encyclopedia. Semin Respir Crit Care Med.

However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have been reported, raising the question of whether techniques that are useful in the diagnosis of gonadal seminoma are applicable to its mediastinal counterpart. Click here for patient related inquiries.

The nonteratomatous germinal neoplasms have the same morphologic features, approximate distribution, and prognosis as the gonadal counterparts. Germinoma-seminoma is the most mdeiastinum nonteratomatous malignant germ cell tumor. Accessed December 31st, Mesothelioma Malignant solitary fibrous tumor. Home About Us Advertise Amazon. Excised tumor with rib. Epidemiology Usually males Geminoma description Invasive, highly necrotic Microscopic histologic ggerminoma Poorly differentiated, pleomorphic cells with prominent nucleoli, often with eosinophilic intracellular globules or primitive lumina; variable geographic necrosis No nuclear blebs Microscopic histologic images Images hosted on other servers: