FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM PDF

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Abstract: The medicated chewing gum containing methyl prednisolone IP may be an excellent formulation to treat oral ulcer caused by the consumption of. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. The new drug delivery system was obtained , at room. Formulation and evaluation of medicated chewing gum as antiplaque and antibacterial agent. S Vasudha Lakshmi1, Hemant KS Yadav1*, KP Mahesh2, Swati.

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Pharmaceutica Analytica Acta Open Access. Chewing gum, chitosan, chlorhexidine, dental caries.

Motion Sickness Susceptibility, Autonomic Neuroscience: His Research Guide is Dr. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.

A Modern Era of Drug Delivery, international research journal of pharmacy, ; 2 In the present study, an attempt has been made to formulate the chewing gum of Dolasetron.

The resulting chewing gum comprises a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing.

FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF DOLASETRON AS AN ANTIEMETIC AGENT

As the proportion of gum base was increased, an increase in hardness of the chewing gum was observed. Volume 7, Issue 4, July-August Paresh Mohan completed B. Ann Jose ankara escort. Analysis of variance revealed ad differences between subjects receiving F1 and F5 for antiplaque activity.

Chitosan containing chewing gum has a greater antibacterial effect compared with gums containing only chlorhexidine. The formulation, which contains highest concentration of chitosan, showed more in vitro vormulation compared to other formulation. The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment.

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Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Journal of Current Pharma Research ; 4 4: From this study, we can conclude that the medicated chewing formulation can be a better choice in the coming years which provides cheding benefits and also benefits commercially. Madan N, Rathnam A.

Formulation And Evaluation Of Medicated Chewing Gum Of Metaclopramide |

Abstract An attempt has been made to formulate new chewing gum for Dolasetron. The new drug delivery system was obtained, at room temperature conventional pharmaceutical equipment.

Hot melt technique was used to prepare chewing gums. Chewing gums were prepared by using chlorhexidine and various proportions of gum base and chitosan.

Formulation and evaluation of medicated chewing gum of Metaclopramide. Presently he is an M. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol F IIIand Castor oil F II but castor oil shows optimum result against glycerol combination, which is formulation II. To carry out in vivo study on humans double-blind, crossover clinical trial was conducted on 18 adult volunteers from Department of Oral Medicine and Radiology, JSS Dental College, Mysore.

Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication. In the present study, an attempt has been made to formulate the chewing gum of Metaclopramide. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Dolasetron for bypassing the hepatic first pass effect.

Agri and Aquaculture Journals Dr. Chlorohexidine Gluconate, Scholars Research Library, ; 2: The in vivo studies on human volunteers were carried out for optimized formulation F5 containing chitosan and antibacterial agent which showed a better reduction in the bacterial count and gingival index.

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Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, eavluation the delivery of the major part of the dose occurs during mastication. Publication Policies and Ethics. Guidelines Upcoming Special Issues. Authors are permitted and encouraged to post their work online e.

The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing.

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Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. The aim of this study was to formulate chewing gum using chlorhexidine and chitosan and to prove its antibacterial and antiplaque properties effectively at low doses of chlorhexidine.

Pharmaceutical Sciences Journals Ann Jose ankara escort. The volunteers were visually examined for presence or absence of gingival erythema, gingival edema and gingival bleeding and the antibacterial activity was assessed by the reduction in bacterial count in the plaque samples.

Fomrulation prepared gums were evaluated for physical parameters, compatibility studies, drug content, moisture content, stability studies and in vitro drug-release testing.

Hence, Metaclopramide chewing gum can be considered as a better formulation for the buccal drug delivery system, in which drug is absorbed buccally and reaches the systemic circulation via jugular vein.

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