FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM PDF

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Abstract: The medicated chewing gum containing methyl prednisolone IP may be an excellent formulation to treat oral ulcer caused by the consumption of. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. The new drug delivery system was obtained , at room. Formulation and evaluation of medicated chewing gum as antiplaque and antibacterial agent. S Vasudha Lakshmi1, Hemant KS Yadav1*, KP Mahesh2, Swati.

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Analysis of variance revealed significant differences between subjects receiving F1 and F5 for antiplaque activity. Hence, Metaclopramide chewing gum can be considered as a znd formulation for the buccal drug delivery system, in which drug is absorbed buccally and reaches the systemic circulation via jugular vein.

Announcements Editorial Board Indexing Contact. Evaluatio melt technique was used to prepare chewing gums. The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment.

Chlorohexidine Gluconate, Scholars Research Library, ; 2: The new drug delivery system was obtained, at room temperature conventional pharmaceutical equipment.

Formulation And Evaluation Of Medicated Chewing Gum Of Metaclopramide |

Guidelines Upcoming Special Issues. Publication Policies and Ethics. The resulting chewing gum comprises a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during anv and chewing.

Urinary excretion profile showed that within the short span of time 1. Motion If Susceptibility, Autonomic Neuroscience: The test group administered chewing gums containing chlorhexidine, with and without the polymer, while the control group administered dummy chewing gums. Paresh Mohan completed B.

Authors who publish with this journal agree to the following terms: Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Metaclopramide for bypassing the hepatic first pass effect.

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The volunteers were visually examined for presence or absence of gingival erythema, gingival edema and gingival bleeding and the antibacterial andd was assessed by the reduction in bacterial count in the plaque samples. The prepared gums were evaluated for physical parameters, compatibility studies, drug content, moisture content, stability studies off in vitro drug-release testing.

Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Dolasetron for bypassing the hepatic first pass effect. Presently he is an M. Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication.

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The in vivo studies on human volunteers were carried out for optimized formulation F5 containing chitosan and antibacterial agent which showed a better reduction in the bacterial count and gingival index. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol F IIIand Castor oil F II but castor oil shows optimum result against glycerol combination, which is formulation II.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.

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Ezhumlai K, Rajalakshmi A. In the present study, an attempt has been made to formulate the chewing gum of Dolasetron.

Downloads Download data is not yet available. As the proportion of gum base was increased, an increase in hardness of the chewing gum was observed. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. His Research Guide is Dr. The formulation, which contains highest concentration of chitosan, showed more in vitro release compared to other formulation. Naik H, Gupta S. A Modern Era of Drug Delivery, international research journal of pharmacy, ; 2 The 5- Hydroxytrytryptamin Receptor Antagonist as Antiementis: Pharmaceutical Sciences Journals Ann Jose ankara escort.

Evaluatjon Analytica Acta Open Access.

Vol 7 No 4 The aim of this study cnewing to formulate chewing gum using chlorhexidine and chitosan and to prove its antibacterial and antiplaque properties effectively at low doses of chlorhexidine. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet.

FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF DOLASETRON AS AN ANTIEMETIC AGENT

Open Access Pharmaceutics Research Journal. Chitosan containing chewing gum has a greater antibacterial effect compared with gums containing only chlorhexidine.

Chewing gumChitosanChlorhexidineDental Caries.

The dose of chlorhexidine can be reduced significantly when used along with chitosan. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated.