BACKGROUND: Flavobacterium meningosepticum is an uncommon pathogen causing nosocomial pneumonia and meningitis in newborns. It is usually. Elizabethkingia meningoseptica is a gram-negative rod-shaped bacterium widely distributed in . Flavobacterium meningosepticum King, (Approved Lists, ); Chryseobacterium meningosepticum (King, ) Vandamme et al., . Flavobacterium meningosepticum is a gram negative, opportunistic organism which has been implicated in a number of outbreaks of sepsis and meningitis in.
View more in-depth experimental data. Hypoalbuminemia, increased pulse rate at the onset of infection, and central venous line infection were associated with a poor outcome.
The organism was resistant to penicillins, cephalosporins, aztreonam, imipenem, meningoseepticum and macrolides.
V Q 12H alongwith ceftazidime mg I.
RCSB PDB – 2GAW: WILD TYPE GLYCOSYLASPARAGINASE FROM FLAVOBACTERIUM MENINGOSEPTICUM
He has subsequently been reviewed at 9 months of age and has significantly developmental delay with increased tone in both lower limbs. Views Read Edit View history. This journal is a member of and subscribes to the principles meninbosepticum the Committee on Publication Ethics.
Elizabethkingia meningoseptica Wet raised colonies with clear margin and characteristic smell after culturing on blood agar.
Flavobacterium meningosepticum bacteremia: an analysis of 16 cases.
In the bacterial GA crystals, we observe a heterotetrameric structure similar to that found in the human structure, as well as that observed in solution for eukaryotic glycosylasparaginases. Treatment with intraventricular erythromycin. Elizabethkingia meningoseptica KingKim et al. We also describe the structure of a mutant wherein the N-terminal nucleophile Thr is substituted by a cysteine.
flavobacterimu Treatment was continued for two more weeks after documenting sterilization of CSF when rifampicin and ceftizoxime were discontinued. Although the organism was resistant to rifampicin and ceftazidime on disc diffusion testing, ceftizoxime was not readily available and an interim therapy was initiated with these drugs. Inthe American bacteriologist Elizabeth O.
Patient was discharged home however, with instructions to return for repeat CSF examination. An automated but so far relatively reliable Rapid NF plus system and API Zym systems use an array of biochemical tests for better identification of nonfermenters and other bacteria and can specifically identify E. Twenty-four antimicrobial agents were tested using antimicrobial susceptibility tests.
Exchange transfusion was performed and the baby was mechanically ventilated. Epidemic meningitis of the newborn caused by flavobacteria. Cranial computerized tomography was performed on seventh hospital day and showed dilatation of ventricular system with contrast enhancement suggestive of ventriculitis.
At AKUH the baby was meningospticum to be hypotonic with no spontaneous movements. Journal of Microbiology, Immunology and Infection. Retrieved from ” https: Flavobacterium meningosepticum is an uncommon pathogen causing nosocomial pneumonia and meningitis in newborns.
In this study, we report the crystal structure of recombinant GA from Flavobacterium meningosepticum. This is version 1.
Reducing the use of unnecessary residual devices and invasive procedures may help reduce the incidence of infection. Meningitis caused by an unclassified gram-negative bacterium in newborn infants. Glycosylasparaginase GA is a member of a novel family of N-terminal nucleophile hydrolases that catalytically use an N-terminal residue as both a polarizing base and a nucleophile. Epidemic meningitis of the newS horn caused by flavobacteria.
KingKim et al. Testing with lomefloxacin, ciprofloxacin and ofloxacin yielded Subcommittee on the taxonomy of Flavobacterium and Cytophaga -like bacteria. Fifteen patients contracted F meningosepticum from nosocomial sources.
Bacteremia occurred in these patients within a mean period of 2. Indian J Med Res. While the pathogen often results in high mortality and serious sequelae in newborns, it is also found to cause to disease in adults.
The suspected infection flavobactedium was not identified in only one patient.