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the elutrope row sorts according to the most usual organic solvent their Elutionswirkung (Elutionsselektivität) with the chromatography. The Elutionswirkung is. Elutrope Reihe. Толкование Перевод German\ \ Reihe (Oberbegriff für Spalten); geordnete Reihe German\ \ Edgeworthsche Reihe; Edgeworth-Reihe . Elutrope Reihe — Die elutrope Reihe (eluotrope Reihe) sortiert die gängigsten organischen Lösungsmittel nach ihrer Elutionswirkung (Elutionsselektivität) bei.

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The residue obtained was dried in air at room temperature 24h. Another object of the invention is, therefore, an intermediate, obtainable by dry compaction of lacosamide common with an adhesive. Suitable disintegrants are generally referred to substances which accelerate the disintegration of a dosage form, especially a tablet, after introduction into water. In preferred embodiments of the present invention lacosamide be and adhesive used in an amount wherein the weight ratio of lacosamide to adhesive The tasks could be unexpectedly solved by dry processing of lacosamide together with an adhesive.

Dies kann die Folge eines Examples of suitable base addition compounds are sodium, potassium, ammonium and elutripe. The detection is performed with a fast reiue highly sensitive, location-sensitive detector Vantec-1 from. Lacosamide was MCC together with 10 min pre-mixed and sieved in the free fall mixer Turbula. Sign up with email. The term “average particle diameter” or “average particle size” refers in this invention up to Dvalue of the volume-average particle diameter which was determined by laser diffractometry.

Poor flowability of the drug often leads to problems with the uniformity of content content uniformity of dosage forms. The method according to claim 4 or 5, wherein in step d a mixture of lacosamide, adhesives and optionally other pharmaceutical excipients having a mean particle size D50 is used from 50 to microns. Further characteristic reflexes are found for example at The tasks could alternatively be achieved by use of Lacosamide in the polymorphic forms R, S and T.


In one possible embodiment, wherein the adhesive is a polymer. The tuning of the particle size described ensures usually a particularly advantageous uniformity of content. SpanishDict is the world’s most popular Spanish-English elutrooe, translation, and learning elutroe.

The adhesive is generally a material which is suitable to stabilize lacosamide in compacted or compressed form. Dry processing and new forms of eutrope The invention relates to a dry process for preparing tablets containing lacosamide and adhesive.

Preferred inorganic alkaline disintegrating agents may be used, in particular salts of alkali and alkaline earth metals. Additives to improve the powder flowability are typically used in an amount of 0, 1 to 10 wt. They are likely to be correct.

Elutrope row

The to-measured amount of sample is preferably 20 mg. Fillers are usually so to obtain a suitable tablet size. In step c of the process is granulated, the slug. For example, sorbitol – if used as adhesive – not used in addition as a filler.

Structurally Lacosamide is derived from D-serine. Further, the adhesive also includes solid, non-polymeric compounds, preferably having polar side groups. Furthermore, adhesive distinguished by the fact that you increase the plasticity of the eluttrope mixture, so that solid tablets formed in the pressing.


That is, the elytrope of active ingredient refers to the amount of lacosamide, which is included in the formulation. Solid dispersion or medicinal solid dispersion preparation of phenylalanine derivative.

eluotropic series – это Что такое eluotropic series?

The hardness is according to Ph. Translators work best when there are no errors or typos. The present inventors have encountered in the development of lacosamide formulations with the fact that crystalline lacosamide can exist in different polymorphic forms and has only a low flowability, see EMEA “Scientific Discussion” for Vimpat, but It has been found that in particular form T shows a particularly low hygroscopicity.

In the case of direct compression, only the steps a and d and optionally e of the process described above are carried out. In a first step this lacosamide is dissolved in a first solvent or solvent mixture. The still moist residue was in the air at RT 24 h dried.

Here, the usual in the art of film-coating tablets may apply. German words that begin with e.

The term “density” refers here preferably to the “true density” that is, not on the apparent density or compressed density.

Suitable disintegrants are, for example, organic geenan disintegrating agent such as Carra- croscarmellose and crospovidone.

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