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La dermatitis herpetiforme constituye una enfermedad crónica, hereditaria, de base inmune, que afecta preferentemente a la población del norte de Europa. La dermatitis herpetiforme es una enfermedad ampollosa autoinmune que aparece como expresión cutánea de la intolerancia al gluten. Forma parte de un . Dermatitis herpetiformis in Brazilan male celiac disease patients: a case series. Dermatitis herpetiforme en hombres brasileños con enfermedad celiaca: una.

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December Pages DH is a specific manifestation of coeliac disease.

Dermatitis herpetiformis

The main autoantigen of dermatitis herpetiformis is epidermal transglutaminase eTGa cytosolic enzyme involved in cell envelope formation during keratinocyte differentiation. The symptoms range in severity from mild to serious, but they are likely to disappear if gluten ingestion is avoided and appropriate treatment is administered.

Inflammation in the gut is similar to, and linked to, celiac disease. JANO,pp. Discussion Our study documented that DH is commonly associated to CD in Derrmatitis male patents in a similar way that reported from European and North American studies, suggesting that geographic differences are not influenced in these diseases 2,4. Dermatitis herpetiformis is characterized by intensely itchychronic papulovesicular eruptions, usually distributed jerpetiforme on extensor surfaces buttocks, back of neck, scalp, elbows, knees, back, hairline, groin, or face.

HONselect – Dermatitis Herpetiformis

All the evaluations were conducted by the same physician at the moment of diagnosis, once a month up to the 6 th month after diagnosis, and then every six months. Clin Exp Immunol,pp. The prevalence of thyriod auto-antibodies in dermatitis herpetiformis. Although dapsone has been shown to be effective for symptomatic treatment, initiation of a gluten free diet for all one’s life is essential.


Incidence and prevalence of dermatitis herpetiformis in a country in central Sweden, with comments on the course of the disease and IgA deposits as diagnostic criterion. It is estimated that these deposits may resorb after ten years of following a gluten-free diet.

Because of the intense itching, patients usually scratch, which may lead to the formation of crusts. Although all DH patients presented gluten sensitivity, the great majority were asymptomatic regarding the digestive point of view.

Malignant lymphoma and dermatitis herpetiformis.

In our study, bloating, chronic diarrhea and abdominal pain were the main digestive symptoms referred. Are you a health professional able to prescribe or dispense drugs?

Dapsone is the drug of choice. Circulating autoantibodies to tissue transglutaminase differentiate patients with dermatitis herpetiformis from those with linear disease.

Orphanet: Dermatitis herpetiforme

Gastroenterologists treating patients with CD must be alert for skin manifestations of gluten sensitivity and other associated diseases.

The spectrum of gluten sensitive enteropathy. Am Fam Physic, 55pp. Macrophages secrete more IL-8, propagating the neutrophil-mediated inflammatory response. Retrieved 27 September Go to the members area of the website of the AEDV, https: Clin Inmunol Inmunopathol,pp. Only comments written in English can be processed. Additionally, we recommend obtaining duodenal biopsies because this first evaluation of the intestinal mucosa is useful for the future, especially if a suspicion of malignancy lymphoma exists 1,3.


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CD was diagnosed based on clinical, herpftiforme, and histological findings Marsh’s classification 1. Br Med J,pp. Itching is typically reduced within 2—3 days, [13] [24] however, dapsone treatment has no effect on any intestinal damage that might be present.

Diagnoses of DH was based on clinical and histological findings in skin biopsies. IgA deposits may form if the antibodies cross-react with epidermal transglutanimase eTG. Clearence of skin lesions in dermatitis herpetiformis after gluten withdrawal.

In the first stage, the patient may notice a slight discoloration of the skin at the site where the lesions appear. Our study herpetiforke that DH is commonly associated to CD in Brazilian male patents in a similar way that reported from European and North American studies, suggesting that geographic differences are not influenced in these diseases 2,4. An Exp Pediatric, 37pp. The same was observed regarding the mean age of occurrence third or fourth decadeas well as with diagnostic delay 4,8 Table II.

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