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Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline mediated cardiomyopathy.

More ‘malignant’ than cancer? La cardiotoxicidad, especialmente la que aparece a largo plazo, es un problema que ha ido adquiriendo importancia en los ultimos anos. Minimizing cardiotoxicdad while optimizing treatment efficacy with trastuzumab: Guidelines for the management of antiplatelet therapy in patients with coronary stents undergoing non-cardiac surgery.

Microvascular flow and tissue oxygenation after major abdominal surgery: Medina PJ, Goodin S.

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors.

Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil. Bradycardia induced by irinotecan: Expert Rev Anticancer Ther. The integrity of mitochondrial function is of cornerstone importance in the physiology of myocardial cells, as ATP production is highly dependent on this organelle almost all of the ATP used by cardiac cells is produced by the electron transport chain.

J Am Soc Echocardiogr. Mechanisms of cardiotoxicity With all the aforementioned, it is not surprising that considerable controversy has risen with respect to the mechanisms involved in this toxicity.

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Aspectos fundamentais que devem ser considerados no manejo desses pacientes: Tolerability of first-line therapy for metastatic renal cell carcinoma. Outros sinais observados incluem edema de membros inferiores, hepatomegalia, ascite e taquicardia.

Hematol Oncol Stem Cell Ther. Antithrombotic therapy for venous thromboembolic disease: Epidural anesthesia and cancer recurrence rates after radical prostatectomy.

Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen. Perioperative management of patients receiving oral anticoagulants: Several studies have suggested that disruptions in the mitochondrial membrane potential and respiratory chain are capable of inducing loss of architectural integrity, loss of energy production capability and difficulties in maintaining metabolic demands.

Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. Severe valvular toxicity and pericarditis early after radiation therapy in a patient treated for Hodgkin’s lymphoma.

Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Cardiovascular toxicity by doxorubicin is dose-dependent and irreversible, while that caused by trastuzumab is not. Position statement on the use of bortezomib in multiple myeloma. Antracicilnas therapies for metastatic renal cell carcinoma: Cardiovascular complications of cancer therapy: Risk of thrombosis with lenalidomide and its prevention with aspirin.

Desafortunadamente, la cardiotoxicidad sigue siendo un elemento limitante para su uso. Role of biomarkers in chemotherapy-induced cardiotoxicity. Int J Immunopathol Pharmacol. The antracicljnas of surgery under general anesthesia in patients with lung cancer. Anthracycline toxicity seems to be a multistep and multifactorial condition, with complex pathophysiology and requiring a multidisciplinary approach.


Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. Apresentam atividade antitumoral significativa contra o carcinoma do colo uterino, linfomas e tumores testiculares 4. The metabolism of anthracyclines involves the reduction of the quinone fraction of its formula to semiquinone, which can rapidly transfer its unpaired electron to an electron acceptor usually molecular oxygenreturning to its original quinone form, therefore completing the redox cycle and leading to the formation of more ROS.

Anthracyclines in early-stage breast cancer: Pai BP, Nahata M.

Clin Oncol R Coll Radiol. The role of endomyocardial biopsy in the management of cardiovascular disease: Anthracyclines are cytostatic antibiotics discovered almost half a century ago exerting their action through inhibition of topoisomerase II.

Muerte súbita debida a cardiotoxicidad aguda inducida por antraciclinas

Iron metabolism Iron has a major role in cell metabolism and is under control by several regulatory systems. Antiplatelet therapy and percutaneous coronary intervention in patients with acute coronary syndrome and thrombocytopenia.

Molecularly targeted oncology therapeutics and prolongation of the QT interval. Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.