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AIDS cholangiopathy is a biliary syndrome in patients with AIDS. This entity is diagnosed on the basis of clinical features, raised alkaline phosphatase, evidence. AIDS cholangiopathy is a well-documented biliary syndrome in severely immunocompromised AIDS patients[9]. It occurs when strictures in the. As it was suspected that the patient suffered from AIDS cholangiopathy, further laboratory studies were obtained. A stool study for Isospora ova.

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AIDS-related cholangitis is most commonly reported in young men who have sex with men with a mean age of 37 years[ 21 ]. The classic laboratory profile in AIDS cholangiopathy is an alkaline phosphatase that is five- to seven-times the upper limit of normal and a moderate increase in transaminase levels.

Journal Information of This Aixs. Ma YJ L- Aida When there is involvement of the intrahepatic ducts, Cryptosporidium and CMV infection are more likely than when the intrahepatic ducts are not involved [ 10 ].

View at Google Scholar J. Imaging features of AIDS cholangiopathy versus primary sclerosing cholangitis. Treatment is recommended with oral trimethoprim-sulfamethoxazole in addition to ivermectin for isospora[ 51 ].

In cholangkopathy one-fourth of patients, the presentation of AIDS cholangiopathy is subtle and not associated with any biochemical abnormalities despite the evidence of cholangiographic abnormalities on imaging studies[ 3536 ]. It is unknown if the different subtypes are a continuum of one disease process [ 21 ]. In our patient, MRCP showed a dilated common bile duct and subtle irregularities of the intrahepatic ducts. Remarkable improvement was reported in the median survival of the patients with AIDS cholangiopathy during the last decade, including reports of up to 34 mo median survival.


The combination of papillary stenosis and intrahepatic ductal strictures is relatively unique to AIDS cholangiopathy [ 5 ]. However, there was no significant improvement in the level of alkaline phosphatase, and progression of intrahepatic sclerosing cholangitis was observed.

International Journal of Hepatology

Diseases of the liver and biliary tree have been described with significant frequency among patients with human immunodeficiency virus HIVand its advanced state, acquired immunodeficiency syndrome AIDS. The survival of patient with AIDS cholangiopathy is generally poor because of disease association with advanced stages of immunosuppression and the presence of multiple opportunistic infections. Liver involvement in human immunodeficiency virus infection. Citation of this article.

The left intrahepatic ductal system is more severely involved than the right side in most cases. Several case series and reviews are published highlighting the clinical, biochemical, and endoscopic management of AIDS-related cholangiopathy.

February 1, Published online: Elevated liver enzymes, especially markedly elevated alkaline phosphatase and gamma-glutamyl transferase GGTis the aidd common biochemical abnormality associated with AIDS cholangiopathy.

Ursodeoxycholic acid has a limited benefit in patients with sclerosing cholangitis and cholestasis. Ursodeoxycholic acid has been used in patients with AIDS cholangiopathy, given that the intrahepatic changes are similar to those found in primary sclerosing cholangitis.

The objective of this review is to summarize the available literature on AIDS cholangiopathy, emphasizing its epidemiology, course of disease, and determinants, while also revealing an updated approach for its evaluation and management. Microscopically, the changes of AIDS cholangiopathy are usually cholangiopathhy with sclerosing cholangitis[ 37 ]. In addition, the HIV-1 Tat protein causes release of full-length FasL in infected cells; consequently, apoptotic cell death in uninfected cholangiocytes leads to damage of adis biliary epithelia, which occurs almost exclusively in patients infected with HIV[ 2627 ].


Radionuclide hepatobiliary aidds HIDA can detect duct dilatation but has been supplanted by other imaging modalities. Though albendazole has been used with some success in disseminated Enterocytozoon intestinalis infection including cholangitis, the therapeutic effect seems cholangioptahy be transient[ 49 ]. Biliary brushings or aspirated biliary fluid may help make the diagnosis of Cryptosporidium or Microsporidia. Cytomegalovirus cholangitis and pancreatitis in an immunocompetent patient.

December 25, First decision: Gastroenterology and hepatology Country of origin: Curr Treat Options Gastroenterol.

Her family history was unremarkable. Treatment of opportunistic infections is surprisingly ineffective in halting the progression of sclerosing cholangitis and papillary stenosis. Deep venous thrombosis was confirmed, and a CT scan of the chest disclosed no pulmonary emboli. Herein, we describe a seventy-four-year-old woman who presented with unilateral leg swelling after a prolonged airplane flight. She had not been sexually active in more than thirty years.

Epidemiology, determinants, and management of AIDS cholangiopathy: A review

Common bile duct dilatation and a mural thickening of an acalculous gallbladder were often noted [ 5 ]. Cholangiopathy in HIV-infected patients.

Abnormalities in liver chemistries are common among HIV-infected persons, even in the absence of hepatitis B and C infections. CD4 count, severity of cholangiopathy, and sphincterotomy for decompression of the biliary tract each have no effect on mortality.