FORMULASI SUSPENSION PDF

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Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Open in a separate window. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. According to the viscosity curves, the suspensions were pseudo plastic, i.

All other chemicals were suspenwion fromMerck, Darmstadt, Germany. After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed.

This article is based on a thesis submitted for Pharm Dr degree No. A sample viscosity curve for formulated suspension. Remington the science and practice of Pharmacy. Table 1 Composition of selected formulations designed in Minitab ver. Eur J Pharm Sci. An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae.

Discussion General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no formuulasi growth and appropriate pour ability. Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Percent of labeled amount.

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Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Designed sjspension axetil formulations had good qualities and could be added as a new product to Iran drug marketing. According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. Evaluation of physical stability Suspeneion formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

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Considering no sedimentation, the sedimentation volume was determined syspension be 1. Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available.

The potential of the moving layer around each particle is called zeta potential. After calculating the viscosity, the curves of viscosity against shear rate were plotted. Percentage of release for all selected formulations.

The degrees of flocculation were also equal to 1. Table 2 Suspenwion of assay test. Tabibi S, Rhodes Susprnsion. Assay test Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Journal List Adv Pharm Bull v. Eur J Pharm Biopharm. Pharmaceutical suspensions from formulation to manufacturing. The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer.

The sedimentation volume was calculated to be 1 in all the suspensions, therefore there was no need to re-dispersion test and the degree of flocculation value was also 1.

Then using equation derived from calibration curve. Tabriz, Iran for the supply of cefuroxime axetil. J Pharm Biomed Anal. Quantity of zeta potential can indicate the potential stability of the colloidal system, if the particles have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other.

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Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added. Published online Dec Oral route is the selective method for administration of most of the drugs. Also the system was found to be time-depended.

Please review our privacy policy. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat forumlasi healthy volunteers. There was no sediment in selected formulations and the sediment volume was 1 for all of them so there was no need for re-dispersion test and the degree of the flocculation was also 1 that was probably because of the high viscosity of the system.

One of the methods for making the forrmulasi, is the dispersion of a particle in a vehicle that suspehsion be done by mechanical instruments or by the use of surfactants that contains three steps: Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.